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Related Experiment Video

Updated: Mar 30, 2026

Author Spotlight: A Reproductive Hysteroscopy Approach for Complete Endometrial Polyp Removal and Enhanced Endometrial Receptivity

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Published on: August 2, 2024

Endometrial receptivity array: Clinical application.

Nalini Mahajan¹

¹Department of Reproductive Medicine, Nova IVI Fertility, New Delhi, India.

Journal of Human Reproductive Sciences

|November 6, 2015

Summary

This summary is machine-generated.

Diagnosing endometrial receptivity (ER) is challenging. The ER array (ERA) test identifies a displaced window of implantation (WOI) in recurrent implantation failure (RIF) patients, improving pregnancy rates with personalized embryo transfer (pET).

Keywords:

ERA Endometrial receptivity in-vitro fertilization recurrent implantation failure thin endometrium

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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Area of Science:

Reproductive Medicine
Genomics
Embryology

Background:

Accurate diagnosis of endometrial receptivity (ER) is crucial for human implantation but remains challenging due to subjective and inaccurate tests.
Microarray technology has identified the transcriptomic signature of the window of implantation (WOI), leading to the development of molecular diagnostic tools.

Purpose of the Study:

To evaluate the efficacy of the Endometrial Receptivity Array (ERA) test in diagnosing ER and improving reproductive outcomes in patients with recurrent implantation failure (RIF).
To assess the utility of ERA in patients with thin endometrium and its impact on pregnancy rates.

Main Methods:

The Endometrial Receptivity Array (ERA) test, a molecular diagnostic tool based on microarray technology, was used to determine ER.
Personalized embryo transfer (pET) was performed on the day designated by ERA in patients with RIF.
ERA was also conducted in patients with persistently thin endometrium (≤6 mm).

Main Results:

An endometrial factor was identified in 27.5% of Indian RIF patients, significantly higher than in the non-RIF group (15%).
Personalized embryo transfer (pET) resulted in an overall ongoing pregnancy rate of 42.4% and an implantation rate of 33%.
In patients with thin endometrium, 75% showed receptive endometrium, achieving a 66.7% pregnancy rate.

Conclusions:

The ERA test is a valuable tool for diagnosing ER, particularly in identifying displaced WOI in RIF patients.
Personalized embryo transfer guided by ERA significantly improves reproductive performance in RIF patients.
ERA demonstrates potential in assessing ER even in cases of thin endometrium, offering a promising diagnostic approach.