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Targeting ECM Disrupts Cancer Progression
Freja A Venning1, Lena Wullkopf1, Janine T Erler1
1Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH) , Copenhagen , Denmark.
Abstract:
Metastatic complications are responsible for more than 90% of cancer-related deaths. The progression from an isolated tumor to disseminated metastatic disease is a multistep process, with each step involving intricate cross talk between the cancer cells and their non-cellular surroundings, the extracellular matrix (ECM). Many ECM proteins are significantly deregulated during the progression of cancer, causing both biochemical and biomechanical changes that together promote the metastatic cascade. In this review, the influence of several ECM proteins on these multiple steps of cancer spread is summarized. In addition, we highlight the promising (pre-)clinical data showing benefits of targeting these ECM macromolecules to prevent cancer progression.
Insights
The extracellular matrix (ECM) plays a critical role in cancer spread. Targeting deregulated ECM proteins shows promise in preventing cancer progression and metastasis.
Area of Science:
- Oncology
- Biochemistry
- Cell Biology
Background:
- Metastatic complications cause over 90% of cancer deaths.
- Cancer progression involves complex interactions between tumor cells and the extracellular matrix (ECM).
- Deregulation of ECM proteins alters tumor microenvironment biochemistry and biomechanics, promoting metastasis.
Purpose of the Study:
- To review the influence of ECM proteins on cancer spread.
- To highlight therapeutic strategies targeting ECM macromolecules.
Main Methods:
- Literature review focusing on ECM proteins and cancer metastasis.
- Analysis of preclinical and clinical data on ECM-targeting therapies.
Main Results:
- Specific ECM proteins are significantly altered during cancer progression.
- These alterations facilitate multiple steps of the metastatic cascade.
- Promising preclinical and clinical data exist for ECM-targeting interventions.
Conclusions:
- The extracellular matrix is a key regulator of cancer metastasis.
- Targeting ECM proteins represents a promising strategy to inhibit cancer progression.
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