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Related Concept Videos

Drug Therapy01:28

Drug Therapy

401
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
401
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

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A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
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Dosage Regimen: Fixed Dose01:01

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Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
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Therapeutic Drug Monitoring: Overview and Classification01:16

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517
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
517
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

466
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
466
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

333
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
333

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Related Experiment Video

Updated: Mar 30, 2026

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
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Medication Adherence Measures: An Overview.

Wai Yin Lam1, Paula Fresco2

  • 1UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK.

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Medication nonadherence in chronic diseases is a major public health issue. This review guides professionals in selecting tools to measure adherence and understand its causes for better patient outcomes.

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Area of Science:

  • Pharmacology
  • Public Health
  • Health Services Research

Background:

  • Medication nonadherence affects 50% of patients with chronic diseases, leading to poor health outcomes and increased healthcare costs.
  • Improving medication adherence is crucial for managing chronic conditions and reducing healthcare burdens.
  • Understanding the magnitude and reasons for nonadherence is key to developing effective interventions.

Purpose of the Study:

  • To review subjective and objective measures for assessing medication adherence.
  • To provide guidance for selecting appropriate tools to explore medication adherence and its underlying causes.
  • To inform the development of targeted interventions for improving patient adherence.

Main Methods:

  • Review of subjective adherence measures (e.g., self-report, clinician assessment).
  • Review of objective adherence measures (e.g., pill count, electronic medication packaging, database analysis).
  • Analysis of the reliability, practicality, and cost-effectiveness of different measurement approaches.

Main Results:

  • Subjective measures offer insights into patient reasons for nonadherence.
  • Objective measures provide precise data on medication-taking behavior.
  • No single measure is perfect; a combination of methods is recommended.

Conclusions:

  • Selecting adherence measurement tools requires balancing reliability, practicality, and cost-effectiveness.
  • A multimeasure approach is currently the most effective strategy for comprehensive adherence assessment.
  • Accurate adherence measurement is essential for designing successful interventions to improve patient health outcomes.