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Second Surgery in Insular Low-Grade Gliomas.

Tamara Ius1, Giada Pauletto2, Daniela Cesselli3

  • 1Neurosurgery Unit, Department of Neurosciences, Santa Maria della Misericordia University Hospital, Udine, Italy.

Biomed Research International
|November 6, 2015
PubMed
Summary
This summary is machine-generated.

Extent of resection at first surgery is key for preventing tumor recurrence in insular low-grade gliomas. Early surgical intervention impacts outcomes and progression to high-grade gliomas.

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Area of Science:

  • Neurosurgery
  • Oncology
  • Neuro-oncology

Background:

  • Surgery for insular gliomas presents technical challenges, with limited research on tumor recurrence (TR) risk factors.
  • Understanding TR predictors is crucial for managing insular low-grade gliomas (LGGs).

Purpose of the Study:

  • To investigate tumor recurrence (TR) in adult patients with insular LGGs undergoing a second surgery.
  • Identify factors influencing TR after initial treatment for insular LGGs.

Main Methods:

  • Retrospective review of 53 patients with insular LGGs.
  • Analysis of 23 patients who underwent a second surgery for tumor recurrence.

Main Results:

  • Nearly 50% of patients progressed to high-grade gliomas (HGGs) by the time of second surgery.
  • Extent of resection (EOR) at first surgery, ΔVT2T1 value, oligodendroglioma histology, and IDH1 mutation were associated with TR.
  • Multivariate analysis identified EOR at first surgery as the independent predictor for TR.

Conclusions:

  • Extent of resection (EOR) during the initial surgery is the primary predictor of tumor recurrence in insular LGGs.
  • Over 50% of recurrent cases had transformed into HGGs, highlighting the need for optimized oncological management strategies post-first surgery.