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Updated: Mar 30, 2026

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Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
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[Postural orthostatic tachycardia syndrome].
Ugeskrift for Laeger
|November 6, 2015
Summary
Postural Orthostatic Tachycardia Syndrome (POTS) is a complex condition causing rapid heart rate increases when standing. Diagnosis involves a head-up tilt test, with management focusing on lifestyle changes and medication.
Area of Science:
- Neurology
- Cardiology
- Immunology
Background:
- Postural Orthostatic Tachycardia Syndrome (POTS) is a heterogeneous condition.
- It involves dysautonomia and suspected autoimmunity.
- Characterized by abnormal heart rate increase upon standing, leading to cerebral hypoperfusion and sympathoexcitation.
Purpose of the Study:
- To summarize the diagnostic criteria and management strategies for POTS.
- To highlight the key features of this complex neurological disorder.
Main Methods:
- Diagnostic criteria based on head-up tilt test.
- Assessment of heart rate increments (≥30 bpm or >120 bpm).
Main Results:
- The primary diagnostic criterion is a significant heart rate increase during a head-up tilt test.
- Symptoms include cerebral hypoperfusion and sympathoexcitation.
Conclusions:
- POTS management requires a multifaceted approach.
- Treatment involves non-pharmacological methods like stress management and volume expansion.
- Pharmacological interventions focus on heart rate control.
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