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Updated: Mar 30, 2026

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
Published on: August 13, 2013
[Role of innate immunity in tolerance induction]
1Shumakov Institute of Transplantology and Artificial organs.
Innate immunity cells critically influence transplant tolerance and rejection. This review explores their roles and strategies for creating tolerogenic dendritic cells (DCs) to improve transplant outcomes.
Area of Science:
- Immunology
- Transplantation Biology
- Cellular Immunity
Context:
- Transplant rejection remains a significant clinical challenge.
- Innate immune responses play a crucial, yet complex, role in transplant outcomes.
- Understanding these mechanisms is key to developing novel therapeutic strategies.
Purpose:
- To review the multifaceted role of innate immunity in transplant tolerance and rejection.
- To analyze the specific contributions of innate immune cells, including dendritic cells (DCs) and NK cells.
- To explore the potential of generating tolerogenic DCs for therapeutic applications in transplantation.
Summary:
- Innate immunity cells, such as dendritic cells (DCs) and natural killer (NK) cells, are pivotal in governing the balance between transplant acceptance and rejection.
- This review details how these cells orchestrate immune responses post-transplantation.
- It further investigates pathways for engineering tolerogenic DCs to actively promote transplant tolerance and mitigate rejection.
Impact:
- Provides a comprehensive overview of innate immunity's role in transplantation.
- Highlights therapeutic targets for modulating immune responses to enhance graft survival.
- Offers insights into the development of dendritic cell-based therapies for preventing transplant rejection and inducing long-term tolerance.
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11:34A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
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