Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

3.1K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.1K
Binge Eating Disorders01:23

Binge Eating Disorders

750
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
750
Hormonal Regulation01:40

Hormonal Regulation

50.5K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
50.5K
Metabolic States of the Body: The Postabsorptive State01:18

Metabolic States of the Body: The Postabsorptive State

1.6K
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
1.6K
Autonomic Nervous System01:22

Autonomic Nervous System

15.8K
The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
15.8K
Self-Regulation01:25

Self-Regulation

322
Self-regulation, also known as self-control, encompasses a range of cognitive and behavioral processes that allow individuals to adjust their internal states and outward actions to align with socially acceptable norms and long-term goals. It plays a fundamental role in adaptive functioning, from resisting impulsive behaviors to persisting through challenging tasks. While its benefits are widely recognized, self-regulation is not limitless. Muraven and Baumeister's theory posits that...
322

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intestinal interoceptive dysfunction drives age-associated cognitive decline.

Nature·2026
Same author

Exercise-induced activation of ventromedial hypothalamic steroidogenic factor-1 neurons mediates improvements in endurance.

Neuron·2026
Same author

Intestinal interoception: A nexus of environment-body-brain interactions.

Neuron·2026
Same author

Discovery of Fluorinated Ultrapotent Chemogenetic Ligands for PET Imaging and Neural Modulation in Nonhuman Primates.

Journal of medicinal chemistry·2026
Same author

Author Correction: Projectome-based characterization of hypothalamic peptidergic neurons in male mice.

Nature neuroscience·2025
Same author

Turning up the volume: BNST couples internal state to consumption.

Cell·2025

Related Experiment Video

Updated: Mar 30, 2026

Errors as a Means of Reducing Impulsive Food Choice
07:07

Errors as a Means of Reducing Impulsive Food Choice

Published on: June 5, 2016

9.3K

Applying the Brakes: When to Stop Eating.

J Nicholas Betley1, Scott M Sternson2

  • 1Department of Biology, University of Pennsylvania, 433 South University Avenue, Philadelphia, PA 19104, USA.

Neuron
|November 6, 2015
PubMed
Summary

Researchers found specific neurons controlling eating. Dopamine receptor 1 neurons projecting to the lateral hypothalamus rapidly regulate feeding behavior, offering insights into consummatory behaviors.

More Related Videos

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

11.8K
Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research
07:15

Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research

Published on: December 18, 2020

5.1K

Related Experiment Videos

Last Updated: Mar 30, 2026

Errors as a Means of Reducing Impulsive Food Choice
07:07

Errors as a Means of Reducing Impulsive Food Choice

Published on: June 5, 2016

9.3K
Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

11.8K
Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research
07:15

Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research

Published on: December 18, 2020

5.1K

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Neurobiology

Background:

  • The nucleus accumbens is a key brain region involved in regulating motivated behaviors, including feeding.
  • Understanding the neural circuits that control consummatory behaviors is crucial for addressing eating disorders and metabolic diseases.

Purpose of the Study:

  • To identify the specific neural pathways and cell types within the nucleus accumbens that rapidly control feeding behavior.
  • To elucidate the role of dopamine signaling in the regulation of appetite and food intake.

Main Methods:

  • Utilized optogenetic and chemogenetic techniques to manipulate specific neuronal populations in the nucleus accumbens.
  • Employed in vivo calcium imaging to monitor neuronal activity during feeding tasks.
  • Investigated the projection targets of nucleus accumbens neurons using viral tracing methods.

Main Results:

  • Identified a distinct population of dopamine receptor 1-expressing neurons within the nucleus accumbens.
  • Demonstrated that these neurons project to the lateral hypothalamus.
  • Showed that activation or inhibition of these specific neurons rapidly altered feeding behavior in rodents.

Conclusions:

  • Dopamine receptor 1-expressing neurons projecting to the lateral hypothalamus are critical mediators of rapid feeding control.
  • This pathway provides a novel target for understanding and potentially modulating appetite and consummatory behaviors.