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Carotid intima media thickness in obese children: is there an association with hyperlipidemia?

Zehra Esra Önal, Levent Soydan, Hatice Eren Öztürk

    Journal of Pediatric Endocrinology & Metabolism : JPEM
    |November 6, 2015
    PubMed

    Insights

    Obese children exhibit increased carotid intima media thickness and higher lipid levels compared to non-obese children. These findings suggest obesity-related changes may contribute to early atherosclerotic development.

    Area of Science:

    • Pediatrics
    • Cardiology
    • Metabolic Disorders

    Background:

    • Childhood obesity is a growing public health concern.
    • Hyperlipidemia is a known risk factor for cardiovascular disease.
    • Early detection of cardiovascular risk factors in obese children is crucial.

    Purpose of the Study:

    • To investigate the association between hyperlipidemia and carotid intima media thickness (cIMT) in obese children.
    • To compare these parameters between obese and non-obese children.

    Main Methods:

    • A cross-sectional study involving 200 children (6-15 years), divided into obese (BMI > 95th percentile) and control groups.
    • Measurement of fasting lipid profiles (total cholesterol, triglyceride, LDL-C, HDL-C) and carotid intima media thickness (cIMT) via neck ultrasound.
    • Analysis of the relationship between body mass index (BMI), lipid levels, atherogenic index, and cIMT.

    Main Results:

    • Obese children showed significantly higher mean cIMT (right, left, and mean) compared to controls.
    • Obese children had elevated levels of total cholesterol, triglyceride, HDL-C, and LDL-C.
    • While BMI correlated with right and mean cIMT in obese children, no correlation was found between lipid levels and cIMT.

    Conclusions:

    • Obese children demonstrate increased carotid intima media thickness, indicating potential early atherosclerotic changes.
    • Obesity-related vascular changes in children warrant further investigation.
    • Larger population-based studies are needed to confirm these associations and implications for long-term cardiovascular health.
    Abstract

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