Treatment of atypical depression with moclobemide: a sequential double controlled study

A double-blind controlled study of moclobemide and diazepam in patients with atypical depression showed both to be effective antidepressants and anxiolytics. Statistical comparison showed diazepam to be significantly better than moclobemide at week 4. However, by week 8 there was no significant difference between the two drugs for depression scores although diazepam was a significantly better anxiolytic. Side-effects were minimal, and the most common side-effects emerging for both drugs were sleep disturbance and physical tiredness.