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Updated: Jan 22, 2026

Polydimethylsiloxane-polycarbonate Microfluidic Devices for Cell Migration Studies Under Perpendicular Chemical and Oxygen Gradients
Published on: February 23, 2017
Chemical manipulations of tissue oxygenation for therapeutic benefit
1Laboratoire de Radiobiologie Cellulaire (Unité Inserm 247), Institut Gustave-Roussy, Villejuif, France.
Abstract:
Many new approaches are currently being explored to improve cancer treatment through hypoxic cell radiosensitization. Oxygen carriers, calcium antagonists, some drugs which shift the oxygen hemoglobin curve to the right improve the oxygen availability in the tumors. An alternative way to improve radiotherapy or chemotherapy is to increase tumor hypoxia either by shifting the hemoglobin oxygen dissociation curve to the left or by using vasodilators. This paper summarizes main results obtained in that field. The relevance of data obtained from animal experiments to clinical practice will be discussed.
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