Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 30, 2026

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation
08:29

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation

Published on: November 7, 2025

525

Modeling TMS-induced I-waves in human motor cortex.

Jochen Triesch1, Christoph Zrenner2, Ulf Ziemann2

  • 1Frankfurt Institute for Advanced Studies, Goethe University, Frankfurt, Germany.

Progress in Brain Research
|November 7, 2015
PubMed
Summary

This study critically evaluates a computational model of transcranial magnetic stimulation (TMS) and its effects on cortical circuits. We identify limitations and propose extensions to better explain I-wave physiology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toddlers' Active Gaze Behavior Supports Self-Supervised Object Learning.

Developmental science·2026
Same author

Re-assessing the Evidence for MR Abilities in Children Using Computational Models.

Developmental science·2026
Same author

Efficient coding in active perception: A developmental perspective on autonomous control.

Advances in child development and behavior·2026
Same author

Infants and Mobiles: Developing an Understanding of Cause and Effect.

Developmental science·2026
Same author

Simulated Cortical Magnification Supports Self-Supervised Object Learning.

IEEE International Conference on Development and Learning. IEEE International Conference on Development and Learning·2026
Same author

Electroencephalogram microstates in Alzheimer's dementia and mild cognitive impairment: A systematic review and meta-analysis.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026

Area of Science:

  • Neuroscience
  • Computational modeling
  • Electrophysiology

Background:

  • Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique.
  • The precise mechanisms by which TMS activates cortical circuits, particularly I-waves, remain incompletely understood.
  • Previous computational models have attempted to explain TMS-induced I-wave physiology.

Purpose of the Study:

  • To critically evaluate the Rusu et al. (2014) computational model of TMS-induced I-wave physiology.
  • To identify the shortcomings of the existing model in explaining experimental findings.
  • To propose necessary extensions for the model to accommodate new and emerging data.

Main Methods:

  • Critical analysis of the Rusu et al. (2014) computational model.
Keywords:
Computational modelingCorticospinal neuronI-wavesMotor cortexTranscranial magnetic stimulation

More Related Videos

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography
12:13

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Published on: October 7, 2025

847
Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping
09:55

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Published on: June 13, 2025

3.1K

Related Experiment Videos

Last Updated: Mar 30, 2026

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation
08:29

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation

Published on: November 7, 2025

525
Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography
12:13

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Published on: October 7, 2025

847
Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping
09:55

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Published on: June 13, 2025

3.1K
  • Comparison of model predictions with existing experimental data on I-wave physiology.
  • Identification of discrepancies and limitations in the model's explanatory power.

    • Main Results:

    • The Rusu et al. (2014) model successfully explains some key experimental findings on I-wave physiology.
    • Several shortcomings were identified in the model's ability to capture the full spectrum of I-wave phenomena.
    • Specific areas requiring model extension were highlighted based on current and emerging experimental data.

    Conclusions:

    • The Rusu et al. (2014) model provides a valuable framework but requires further development.
    • Extensions are necessary to improve the model's accuracy and predictive power for TMS-induced cortical activation.
    • Further computational modeling is crucial for advancing our understanding of TMS and I-wave neurophysiology.