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Updated: Mar 30, 2026

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction
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HALT & REVERSE: Hsf1 activators lower cardiomyocyt damage; towards a novel approach to REVERSE atrial fibrillation

Eva A H Lanters1, Denise M S van Marion2, Charles Kik3

  • 1Department of Cardiology, Ba 579, Erasmus Medical Center, 's Gravendijkwal 230, 3015, CE, Rotterdam, The Netherlands. e.lanters@erasmusmc.nl.

Journal of Translational Medicine
|November 7, 2015
PubMed

Insights

This study investigates Heat Shock Proteins and atrial electropathology to understand atrial fibrillation progression. Findings may lead to new diagnostic tools for early atrial fibrillation recognition.

Area of Science:

  • Cardiology
  • Biochemistry
  • Medical Research

Background:

  • Atrial fibrillation (AF) is a progressive arrhythmia with unknown mechanisms driving recurrence.
  • Heat Shock Proteins (HSPs), key to cardiomyocyte protein quality control, may mitigate AF progression by reducing atrial remodeling.
  • The HALT & REVERSE study explores the link between HSPs, electropathology, and AF development/recurrence.

Purpose of the Study:

  • To investigate the correlation between Heat Shock Protein levels and atrial electropathology.
  • To assess the role of HSPs in AF progression following cardiac procedures.
  • To identify potential novel diagnostic markers for early AF detection.

Main Methods:

  • Prospective observational study with three groups: cardiothoracic surgery, pulmonary vein isolation (PVI), and electrical cardioversion (ECV).
  • Intra-operative high-resolution epicardial (surgery) or endocardial (PVI) mapping to assess atrial electropathology.
  • Blood and tissue samples collected for HSP analysis; AF recurrence monitored via continuous rhythm monitoring and Holter registration.

Main Results:

  • Data on HSP levels and electropathology measurements were collected across study groups.
  • Correlation analysis between HSP levels and degree of electropathology was performed.
  • AF recurrence rates and timing post-procedure were documented.

Conclusions:

  • The study aims to establish a correlation between HSP levels and the extent of atrial electropathology.
  • Outcomes are expected to inform the development of new diagnostic tools for early clinical atrial fibrillation recognition.
Abstract

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