Related Experiment Video
Updated: Mar 30, 2026
06:48
Author Spotlight: Advancements in 3D Optical Imaging for Comprehensive Body Composition Assessment in Modern Research
Published on: June 7, 2024
2.3K
Application of standards and models in body composition analysis
Manfred J Müller1, Wiebke Braun1, Maryam Pourhassan1
1Institute of Human Nutrition and Food Science,Christian-Albrechts-Universität zu Kiel,Kiel,Germany.
The Proceedings of the Nutrition Society
|November 7, 2015
Summary
This review explores advanced body composition analysis (BCA) models, integrating physiology for detailed phenotyping. Functional and healthy body composition models offer deeper insights beyond basic descriptions for research and clinical use.
Area of Science:
- Physiology
- Biomedical Research
- Body Composition Analysis
Background:
- Current body composition analysis (BCA) methods are reliable and valid.
- Existing models range from 2- to multi-component, with 4-compartment models and whole-body scans as gold standards.
- BCA data are primarily used for descriptive and normative analyses.
Purpose of the Study:
- To extend current concepts of body composition.
- To integrate body composition analysis into physiological understanding.
- To introduce advanced models like functional and healthy body composition.
Main Methods:
- Review of in vivo body composition analysis (BCA) methods.
- Integration of individual body component data into various models (2-, 3-, 4-, multi-component).
- Application of mathematical modeling for functional and healthy body composition concepts.
Main Results:
- Established BCA methods are reliable and valid.
- The 4-compartment model and whole-body scans are considered gold standards.
- Advanced models (FBC, HBC) provide deeper insights into structure-function relationships.
Conclusions:
- Body composition analysis is essential for detailed phenotyping.
- Advanced BCA models support in-depth biomedical research.
- BCA provides a basis for clinical decision-making.
Keywords:
4-Compartment modelADP air displacement plethysmographyBCA body composition analysisCT computed tomographyDXA dual X-ray-absorptiometryFBC functional body compositionFFM fat free massFM fat massFat free massFat massHBC healthy body compositionLST lean soft tissueMRISM skeletal muscleVAT visceral adipose tissue
Related Concept Videos
01:23Mechanistic Models: Compartment Models in Individual and Population Analysis
323
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
323
01:19Body Water Content and Fluid Compartments
5.1K
Life's biochemical processes occur within aqueous solutions. Solutes are substances that are dissolved within these solutions. The human body contains a variety of solutes, which can differ across various body parts. These can encompass proteins—such as those responsible for clotting and carbohydrate transport—as well as electrolytes. In medicine, an electrolyte is often described as a mineral ion derived from a salt possessing an electric charge. Examples include sodium ions...
5.1K
01:14Model Approaches for Pharmacokinetic Data: Compartment Models
738
Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
Two primary types of compartment models are recognized: mammillary and catenary. The more...
738
01:29Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
397
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
397
01:14Multicompartment Models: Overview
701
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
701
01:15Model Approaches for Pharmacokinetic Data: Physiological Models
338
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
338