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Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

14.4K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
14.4K
Olfaction01:25

Olfaction

49.8K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Related Experiment Video

Updated: Mar 30, 2026

Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions
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Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions

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Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis.

Naresh K Hanchate1, Kunio Kondoh1, Zhonghua Lu1

  • 1Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

Science (New York, N.Y.)
|November 7, 2015
PubMed
Summary
This summary is machine-generated.

Mature mouse olfactory neurons express a single odorant receptor gene, unlike immature neurons that express multiple. This developmental process, crucial for smell, appears independent of neuronal activity.

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Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
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Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor

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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
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Related Experiment Videos

Last Updated: Mar 30, 2026

Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions
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Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
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Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor

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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
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Area of Science:

  • Neuroscience
  • Genetics
  • Olfactory System Development

Background:

  • The sense of smell relies on olfactory neurons detecting diverse chemicals as scents.
  • Olfactory neurons express specific odorant receptor genes (Olfrs) to achieve this diversity.

Purpose of the Study:

  • To investigate the developmental mechanisms governing olfactory neuron maturation in mice.
  • To understand how single-cell Olfr gene expression is established during neuronal development.

Main Methods:

  • Utilized single-neuron RNA sequencing.
  • Analyzed gene expression patterns in developing mouse nasal olfactory neurons.

Main Results:

  • Mature neurons predominantly express a single Olfr gene at high levels (~1000 genes available).
  • Immature neurons coexpress multiple Olfr genes at low levels, originating from various chromosomes.
  • Coexpressed Olfrs show regional biases within the nasal epithelium but not single genomic loci.

Conclusions:

  • Olfactory neuron maturation involves a developmental progression restricting Olfr gene expression to one per neuron.
  • This critical developmental step appears independent of neuronal activity and sensory transduction.