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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Overview of Regeneration and Repair01:19

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Vascular Spasm01:16

Vascular Spasm

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The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
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Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Murine Model of Femoral Artery Wire Injury with Implantation of a Perivascular Drug Delivery Patch
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How an artery heals

Kevin Jon Williams1, Ira Tabas2, Edward A Fisher2

  • 1From the Section of Endocrinology, Diabetes, & Metabolism, Temple University School of Medicine, Philadelphia, PA (K.J.W.); Department of Molecular and Clinical Medicine, Sahlgrenska Academy of the University of Gothenburg, Göteborg, Sweden (K.J.W.); Departments of Medicine, Pathology & Cell Biology, and Physiology, Columbia University Medical Center, New York, NY (I.T.); and Department of Medicine (Cardiology), the Marc and Ruti Bell Program in Vascular Biology and The Center for the Prevention of Cardiovascular Disease, NYU School of Medicine, New York, NY (E.A.F.). kjwilliams@temple.edu Kevin-Jon.Williams@wlab.gu.se.

Circulation Research
|November 7, 2015
PubMed
Summary

No abstract available in PubMed .

Keywords:
Editorialatherosclerosisendothelial functionlipids and lipoproteinslow-density lipoproteinmacrophage

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