Related Experiment Video
Updated: Mar 30, 2026
08:58
Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
829
Bronchopulmonary dysplasia - an overview about pathophysiologic concepts.
Sophie Niedermaier1,2, Anne Hilgendorff3,4
1Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich Max-Lebsche-Platz 31, 81377, Munich, Germany. Sophie.Niedermaier@med.uni-muenchen.de.
Molecular and Cellular Pediatrics
|November 7, 2015
Summary
Bronchopulmonary dysplasia (BPD) in preterm infants impairs lung development, with lasting adult effects. This review explores BPD
Area of Science:
- Neonatology
- Pulmonology
- Pathophysiology
Background:
- Bronchopulmonary dysplasia (BPD) is a chronic lung disease in preterm infants.
- It results from impaired pulmonary development with lifelong consequences.
- Key triggers include infection, oxygen toxicity, and mechanical ventilation.
Purpose of the Study:
- To review the pathophysiology of BPD.
- To explore the interplay of disease mechanisms.
- To discuss the long-term effects on adult lung aging and repair.
Main Methods:
- Literature review of pathophysiologic processes in BPD.
- Analysis of cellular and molecular changes.
- Discussion of growth factor signaling in disease development and repair.
Main Results:
- BPD involves sustained inflammation, extracellular matrix remodeling, and apoptosis.
- Altered growth factor signaling is a key feature.
- These changes impact the pulmonary scaffold and cellular interface.
Conclusions:
- BPD's pathophysiology involves complex interactions affecting lung development.
- Long-term consequences include altered adult lung aging and repair processes.
- Understanding these mechanisms is crucial for managing BPD's lifelong impact.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.1K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.1K
01:17Pulmonary Cycle: Exhalation
4.9K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
4.9K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
4.1K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.1K
01:20COPD: Pathogenesis and Clinical Features
2.2K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.2K
01:29Pneumonia II: Pathophysiology
4.1K
The pathophysiology of pneumonia involves the following steps:
4.1K
01:24Chronic Obstructive Pulmonary Disease
3.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
3.2K