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No specific association between primary biliary cirrhosis and bacteriuria?
A Floreani1, M F Bassendine, H Mitchison
1Department of Medicine, University of Newcastle Upon Tyne, U.K.
Journal of Hepatology
|March 1, 1989
Summary
This study found no specific link between primary biliary cirrhosis (PBC) and bacteriuria. The prevalence of urinary tract infections in PBC patients was similar to those with other chronic liver diseases (CLD).
Area of Science:
- Hepatology
- Nephrology
- Autoimmune Diseases
Background:
- Primary biliary cirrhosis (PBC) is a chronic liver disease with an autoimmune basis.
- Bacteriuria, the presence of bacteria in urine, can be a marker for urinary tract infections.
- The relationship between PBC and bacteriuria requires further investigation.
Purpose of the Study:
- To investigate the prevalence and incidence of bacteriuria in patients with primary biliary cirrhosis (PBC).
- To compare bacteriuria rates in PBC patients with those suffering from other chronic liver diseases (CLD) and primary Sjögren's syndrome.
- To determine if there is a specific association between PBC and bacteriuria.
Main Methods:
- A cross-sectional study examined 160 PBC patients, 140 CLD patients, and 28 primary Sjögren's syndrome patients for bacteriuria using midstream urine (MSU) examination over six months.
- A second prospective study assessed the cumulative incidence of bacteriuria in these groups.
- Statistical analysis was performed to identify correlations with age and cirrhosis.
Main Results:
- The overall prevalence of bacteriuria was 11.2% in PBC, 12.1% in CLD, and 10.7% in Sjögren's syndrome patients.
- Bacteriuria prevalence was associated with patient age and the presence of cirrhosis in PBC and CLD groups.
- No significant difference in bacteriuria prevalence was found between PBC and CLD patients overall or within subgroups (females, cirrhotic, non-cirrhotic).
- The prospective study showed no significant differences in the cumulative incidence of bacteriuria between groups, although 34% of PBC patients had positive tests after five months.
Conclusions:
- There is no specific association between primary biliary cirrhosis (PBC) and bacteriuria when compared to other chronic liver diseases (CLD).
- The prevalence of bacteriuria in PBC patients is comparable to that observed in CLD patients.
- Age and cirrhosis are factors influencing bacteriuria in liver disease patients.