Related Experiment Video
Updated: Mar 30, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Tumor antigens in human cancer control
Sander Kelderman1, Pia Kvistborg1
1The Netherlands Cancer Institute, Division of Immunology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Abstract:
The body of evidence that is supporting the role of T cells in human tumor control is substantial and it is now beyond doubt that T cells can be crucial in the clinical response to cancer immunotherapies such as adoptive T cell therapy and checkpoint blockade. This has been proven in particular for melanoma and non-small cell lung cancer. Strikingly, while clinical experience with these therapies is extensive, what these T cells detect on the tumors remains largely unknown. An extensive effort has been put into the characterization of tumor antigens and based on the recent successes of immunotherapies Cancer/Germline, mutated and viral antigens appear rather promising targets for tumor control. Furthermore, it is becoming evident that the most potent antigen in tumor control is highly dependent on the type of malignancy and may also vary even within malignancies.
Related Concept Videos
Tumor Immunotherapy
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and...
The Tumor Microenvironment
The Tumor Microenvironment

