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A useful and easy to develop combined stress test for myocardial perfusion imaging: Regadenoson and isometric

Lucile Janvier^1,2, J Pinaquy³, H Douard⁴

¹CHU de Nancy, Service de Médecine Nucléaire, Hôpital Brabois, 54500, Vandoeuvre-lès-Nancy, France. luciljanvier@gmail.com.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology

|November 7, 2015

Abstract

Background:

Regadenoson, a selective A2a receptor agonist, is a vasodilator increasingly used in myocardial perfusion imaging. Adjunction of isometric exercise is a simple method that could improve side effect profile while providing better image quality.

Methods:

Patients undergoing SPECT MPI were prospectively enrolled in handgrip-Regadenoson (HG-Reg test, N = 20) and Regadenoson (Reg) stress test (N = 40). Investigator blinded to stress test analyzed clinical data and images.

Results:

Heart rate (HR) increase was statistically higher in the HG-Reg group (27 vs 22 bpm, P = .019). Decrease in SBP was less frequent in the HG-Reg group than in the Reg group (55% vs 85.5%, P = .005), there were less drops >10 mmHg (45% vs 77.7%, P = .012). During stress testing, fewer subjects reported at least one side effect in the HG-Reg compared to Reg group (70% vs 92.5%, P = .021). Images were more often classified as good in the HG-Reg group (75% vs 52.5% in the Reg group, P = .25).

Conclusions:

Adjunction of handgrip exercise to Regadenoson administration is a well-tolerated and easy method, without loss of time. Furthermore, image quality seems to be better.

Keywords:

Exercise stress Regadenoson myocardial perfusion imaging vasodilator stress

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