Related Experiment Video

Updated: Mar 30, 2026

Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells
12:16

Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells

Published on: December 17, 2015

27.2K

Genome Sequence of Porphyromonas gingivalis Strain AJW4

Gary Xie1, Ryan P Chastain-Gross2, Myriam Bélanger3

  • 1Bioenergy and Biome Sciences (B-11), Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.

Genome Announcements
|November 7, 2015
PubMed

Insights

Porphyromonas gingivalis causes oral and systemic diseases. Researchers sequenced the genome of AJW4, a P. gingivalis strain with minimal invasion capabilities, aiding in understanding disease mechanisms.

Area of Science:

  • Microbiology
  • Genomics
  • Oral Health

Background:

  • Porphyromonas gingivalis is a key pathogen linked to periodontal disease and systemic conditions.
  • Invasion phenotypes of P. gingivalis strains vary and correlate with disease severity in animal models.

Purpose of the Study:

  • To present the complete genome sequence of AJW4, a P. gingivalis strain exhibiting minimal invasive properties.
  • To provide a genomic resource for understanding strain-specific virulence factors and disease associations.

Main Methods:

  • Whole-genome sequencing of Porphyromonas gingivalis strain AJW4.
  • Bioinformatic analysis to assemble the genome and determine its characteristics.

Main Results:

  • The genome of AJW4 was successfully assembled into a single contig of 2,372,492 base pairs.
  • The G+C content of the AJW4 genome was determined to be 48.27%.

Conclusions:

  • The genome sequence of the minimally invasive P. gingivalis strain AJW4 is now available.
  • This genomic data can facilitate future research into the genetic basis of P. gingivalis invasion and pathogenicity.

More Related Videos

Identification of Novel Genes Associated with Alginate Production in Pseudomonas aeruginosa Using Mini-himar1 Mariner Transposon-mediated Mutagenesis08:57

Identification of Novel Genes Associated with Alginate Production in Pseudomonas aeruginosa Using Mini-himar1 Mariner Transposon-mediated Mutagenesis

Published on: March 10, 2014

12.9K
In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA11:15

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

Published on: May 21, 2015

11.5K

Related Concept Videos

Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
1.2K
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
50.5K
Prokaryotic Gene Structure and Organization01:28

Prokaryotic Gene Structure and Organization

Prokaryotic genomes exhibit a streamlined organization of coding and non-coding regions essential for gene expression and protein synthesis. While coding regions contain the genetic instructions for proteins or functional RNAs, non-coding regions regulate the precise transcription and translation of these genes.Coding Regions: Proteins and RNAsThe primary coding regions, known as structural genes, include sequences transcribed into messenger RNA (mRNA) and ultimately translated into...
2.7K
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
38