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Yeast Signaling

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

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Related Experiment Video

Updated: Mar 30, 2026

Using Microfluidic Devices to Measure Lifespan and Cellular Phenotypes in Single Budding Yeast Cells

Using Microfluidic Devices to Measure Lifespan and Cellular Phenotypes in Single Budding Yeast Cells

Published on: March 30, 2017

Single-cell phenomics in budding yeast.

Yoshikazu Ohya¹, Yoshitaka Kimori², Hiroki Okada³

¹Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa 277-8562, Japan ohya@k.u-tokyo.ac.jp.

Molecular Biology of the Cell

|November 7, 2015

Summary

This summary is machine-generated.

Phenomics, a high-throughput method, is increasingly vital in biology. Advances in cell imaging and analysis of budding yeast (Saccharomyces cerevisiae) offer new insights into cellular processes.

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Area of Science:

Cell biology
Genomics
Biotechnology

Background:

Phenomics, a high-dimensional and high-throughput phenotyping method, is gaining importance in biological research.
Budding yeast (Saccharomyces cerevisiae) serves as a model organism for studying complex cellular processes.
Microscopic imaging with spatial and temporal attributes enhances cell phenotyping reliability and analysis.

Purpose of the Study:

To review recent advancements in cell imaging techniques.
To illustrate the applicability of these techniques to eukaryotic cells.
To demonstrate how these techniques deepen the understanding of budding yeast.

Main Methods:

Review of recent cell imaging technologies.
Application of multivariate analysis to high-resolution phenotyping data.
Microscopic imaging of subcellular structures with spatial and temporal data.

Main Results:

Advanced cell imaging techniques provide high-resolution phenotyping capabilities.
Spatial and temporal attributes improve the reliability and analytical potential of cell phenotyping.
The study highlights the utility of these methods in advancing the understanding of budding yeast.

Conclusions:

Cell imaging and phenomics are powerful tools for biological discovery.
Budding yeast is a valuable system for applying and validating advanced phenotyping methods.
These integrated approaches yield significant biological knowledge.