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The Tussle Between Mycobacteria and Host: To Eat or Not To Eat
Asani Bhaduri1, Richa Misra2, Neeru Dhamija3
1Cluster Innovation Centre, University of Delhi, Delhi, 110007 India.
Abstract:
Autophagy is a catabolic process of cellular homeostasis evolutionarily conserved in eukaryotes. To block infection of intracellular bacterial pathogens, metazoans deploy autophagy for pathogen clearance through phago-lysosome formation and specific bactericidal peptides. Although an array of research have publicized the host regulatory factors, the function of bacterial effectors are yet to be understood in detail. In this article, we focus on the autophagic response to one of the most successful intracellular bacteria Mycobacterium tuberculosis.
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