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Related Concept Videos

Hedgehog Signaling Pathway02:33

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Hedgehog Signaling Pathway02:33

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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What is Homeostasis?01:16

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Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
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Homeostatic Imbalance01:10

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Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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The Hedgehog Hold on Homeostasis.

Ciara Metcalfe1, Christian W Siebel2

  • 1Department of Translational Oncology, Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA.

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Summary

The Hedgehog pathway maintains adult lung quiescence, contrary to its known growth-promoting role. Its attenuation is necessary for lung tissue to regenerate and proliferate.

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Area of Science:

  • Pulmonary Medicine
  • Developmental Biology
  • Cell Signaling

Background:

  • The adult lung exhibits slow epithelial turnover, indicating a quiescent state.
  • The Hedgehog signaling pathway is typically associated with cell proliferation and development.

Purpose of the Study:

  • To investigate the role of the Hedgehog pathway in maintaining adult lung quiescence.
  • To understand the pathway's function in lung regeneration.

Main Methods:

  • Analysis of Hedgehog pathway activity in adult lung tissue.
  • Assessment of lung regeneration following pathway modulation.

Main Results:

  • The Hedgehog pathway actively maintains lung quiescence.
  • Attenuation of the Hedgehog pathway is essential for initiating proliferative regeneration in the lung.

Conclusions:

  • The Hedgehog pathway has a dual role, maintaining quiescence in adult lungs and enabling regeneration upon attenuation.
  • Understanding this pathway is crucial for developing therapies for lung injury and disease.