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Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
Published on: December 27, 2010
Tropism distribution among antiretroviral-naive HIV-2-infected patients
Benoit Visseaux1, Charlotte Charpentier, Alexandra Ozanne
1aINSERM, IAME, UMR 1137 bIAME, UMR 1137, Université Paris Diderot, Sorbonne Paris Cité cAP-HP, Laboratoire de Virologie, Hôpital Bichat, Paris dISPED, Centre INSERM U897, Epidemiologie-Biostatistique, Université Bordeaux eINSERM, ISPED, Centre INSERM U897, Epidemiologie-Biostatistique fAP-HP, Hôpital Bichat, Service de Maladies Infectieuses et Tropicales, Paris, France.
Abstract:
The aim of this study was to describe HIV-2 R5/X4-tropism distribution in antiretroviral-naive HIV-2-infected patients. Population sequencing of the gp105 region was performed on peripheral blood mononuclear cells issued from 151 antiretroviral-naive patients. Tropism was successfully determined in 46 of 151 samples (30%) with six of 46 (13%) X4-tropic viruses. X4-tropism was associated with lower CD4 cell count (337 vs. 551/mm; P = 0.032) but not with plasma viral load. Thus, X4-tropism prevalence in HIV-2 antiretroviral-naive patients is similar to that observed in HIV-1.
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