Related Experiment Video
Updated: Mar 30, 2026

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
Published on: April 16, 2019
Hyperuricemia and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis
Shulan Gong1, Jiqing Song, Luan Wang
1Departments of aEndocrinology bGastroenterology, Affiliated Hospital of Qingdao University, Qingdao cDepartment of Nursing, Yeda Hospital of Yantai City, Yantai, China.
Background:
Previous studies have suggested a possible association between hyperuricemia and nonalcoholic fatty liver disease (NAFLD), but the risk of NAFLD in individuals with hyperuricemia had not been fully quantified. A systematic review and meta-analysis of relevant studies was carried out to estimate the influence of hyperuricemia on the risk of NAFLD.
Methods:
PubMed, Embase, Web of Science, and Wanfang databases were searched for cohort or cross-sectional studies assessing the association between hyperuricemia and NAFLD. Relative risks (RRs) with 95% confidence intervals (95% CIs) were pooled using a random-effects model to estimate the impact of hyperuricemia on the risk of NAFLD.
Results:
Thirteen studies from 12 articles were finally included in the meta-analysis. There were a total of 117,712 participants and 28,446 (24.2%) NAFLD cases. Individuals with hyperuricemia had an obviously increased risk of NAFLD compared with those without hyperuricemia (RR=1.79, 95% CI 1.55-2.07, P<0.001). Increased risk of NAFLD was obviously associated with hyperuricemia in both men (RR=1.26, 95% CI 1.15-1.37, P<0.001) and women (RR=2.01, 95% CI 1.58-2.56, P<0.001). Subgroup analyses further identified the robustness of the association between hyperuricemia and NAFLD.
Conclusion:
Hyperuricemia is associated with an increased risk of NAFLD in Asian populations. Further prospective cohort studies are needed to assess the impact of hyperuricemia on the risk of NAFLD in Western countries.
Related Concept Videos
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):

