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Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata
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Do Stem Cells Have an Effect When We Fat Graft?

Brian D Rinker1, Krishna S Vyas

  • 1From the Division of Plastic Surgery, University of Kentucky, Lexington, KY.

Annals of Plastic Surgery
|November 7, 2015
PubMed
Summary
This summary is machine-generated.

Fat grafting enhances soft tissues, improving scars and irradiated skin quality. While adipose-derived stem cells (ASCs) likely contribute, evidence doesn't yet support routine use of ASC-enriched grafts.

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Area of Science:

  • Plastic Surgery
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Fat grafting is a common method for soft tissue restoration in plastic surgery.
  • Claims suggest fat grafting has regenerative effects on recipient tissues.
  • Adipose-derived stem cells (ASCs) are present in fat grafts and their survival depends on the recipient bed's microenvironment.

Purpose of the Study:

  • To review existing literature on the regenerative effects of fat grafting on surrounding tissues.
  • To determine if fat grafting positively impacts recipient tissue quality.

Main Methods:

  • Literature review of clinical and animal studies on fat grafting.
  • Analysis of studies documenting effects on scar scores, stiffness, and irradiated tissue quality.

Main Results:

  • Fat grafting improves validated scar scores and reduces stiffness in burn scars.
  • It enhances the quality of irradiated tissues, confirmed by clinical scales and histology.
  • Animal studies show significant ASC survival post-engraftment.

Conclusions:

  • Fat grafting effectively volumizes and improves skin quality in areas affected by radiation, burns, and scars.
  • Adipose-derived stem cells are likely responsible for these observed regenerative effects.
  • Current evidence does not support the routine use of ASC-enriched fat grafts.