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CHANGES IN C-REACTIVE PROTEIN AND BIOCHEMICAL PROFILE IN PRESCHOOL CHILDREN WITH OBESITY

Enrique Carmona-Montesinos1, Zugaila Ruiz-Fragoso2, Graciela Ponce-Hinojosa3

  • 1Departamento de Fisología, Facultad de Medicina, UNAM. Hospital Pediátrico San Juan de Aragón, Secretaria de Salud del Distrito Federal.. srivas@unam.mx.

Nutricion Hospitalaria
|November 8, 2015
PubMed

Insights

Childhood obesity in 3-5 year olds significantly elevates C-reactive protein (CRP), triglycerides, LDL, and glucose, while lowering HDL. These metabolic changes highlight the critical impact of early-life obesity on long-term health.

Area of Science:

  • Pediatrics
  • Public Health
  • Metabolic Disorders

Background:

  • Childhood obesity is a significant public health concern.
  • Unchecked weight gain can lead to serious health complications like insulin resistance, dyslipidemia, and metabolic syndrome.
  • Early identification and intervention are crucial for preventing long-term health issues.

Purpose of the Study:

  • To evaluate C-reactive protein (CRP) concentrations, lipid profiles, and glucose levels in obese preschool children.
  • To compare these metabolic markers between obese and eutrophic children aged three to five years.

Main Methods:

  • A cohort of 100 children aged 3-5 years was divided into eutrophic (n=50) and obese (n=50) groups.
  • Anthropometric measurements were taken for all participants.
  • Plasma levels of ultrasensitive CRP, triglycerides, cholesterol, LDL-C, HDL-C, and glucose were quantified.

Main Results:

  • Obese children exhibited significantly higher height, weight, BMI, ultrasensitive CRP, triglycerides, LDL, and glucose levels (p < 0.0001).
  • Obese children also showed significantly decreased HDL levels (p < 0.0001) compared to eutrophic children.
  • All measured metabolic markers showed statistically significant differences between the two groups.

Conclusions:

  • Metabolic alterations in obese preschool children include elevated inflammatory markers and adverse lipid profiles.
  • Preschool age is critical for adipocyte development, influencing lifelong obesity-related complications.
  • Early metabolic changes in obese children underscore the need for timely interventions.
Abstract

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