Related Experiment Videos
[Children of insulin-dependent diabetic patients. A determination of status]
J Schwingshandl1, H Rosegger, J Haas
1Universitäts-Kinderklinik, Graz.
Insights
Maternal diabetes in pregnancy can lead to neonatal complications, particularly with persistent fetal hyperinsulinism. Monitoring insulin levels is crucial for assessing newborn risks and potential health issues.
Area of Science:
- Neonatal Medicine
- Endocrinology
- Obstetrics
Context:
- Pregnancy with insulin-dependent diabetes presents unique challenges for both mother and fetus.
- Understanding the impact of maternal glycemic control on neonatal outcomes is critical.
Purpose:
- To investigate the relationship between maternal diabetes, fetal insulin levels, and neonatal morbidity in newborns.
- To identify key indicators of neonatal complications in infants born to mothers with diabetes.
Summary:
- This study analyzed 143 newborns of mothers with insulin-dependent diabetes, noting mean birth weight and gestational age.
- Neonatal morbidity correlated with diabetes class and insulin levels in amniotic fluid, urine, and cord blood.
- Persistent fetal hyperinsulinism, indicated by high amniotic fluid insulin, was a significant factor in neonatal complications.
Impact:
- Findings highlight the importance of monitoring fetal insulin levels during pregnancy for early detection of potential neonatal issues.
- This research aids in refining management strategies for pregnant individuals with diabetes to improve neonatal outcomes.
Abstract:
We report on 143 newborns of mothers with insulin dependent diabetes during pregnancy. The mean birth weight was 3.091 (+/- 619) g at a mean gestational age of 38.4 (+/- 2) weeks. Neonatal morbidity was associated with the disease class, insulin levels in the amniotic fluid, urine and cord blood; and especially persistent fetal hyperinsulinism as indicated by repeatedly high amniotic fluid insulin levels during pregnancy. One infant died (neonatal mortality 0.69%) of a severe cardiac malformation combined with a caudal regression syndrome. This was the only major malformation in the group.