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Aminations with Hypervalent Iodine.

Kilian Muñiz1,2

  • 1Institute of Chemical Research of Catalonia (ICIQ), 16 Avgda. Països Catalans, 43007, Tarragona, Spain. kmuniz@iciq.es.

Topics in Current Chemistry
|November 8, 2015
PubMed
Summary
This summary is machine-generated.

Hypervalent iodine reagents effectively mediate hydrocarbon amination reactions, including C-H bond functionalization. This review highlights advancements in hypervalent iodine(III) chemistry for various carbon hybridization states.

Keywords:
AlkenesAminationArenesC–N bond formationIodine–nitrogen bonds

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Area of Science:

  • Organic Chemistry
  • Catalysis

Background:

  • Hypervalent iodine compounds are versatile reagents in organic synthesis.
  • Amination reactions are crucial for introducing nitrogen into organic molecules.
  • C-H bond functionalization offers efficient synthetic pathways.

Purpose of the Study:

  • To review recent advancements in hypervalent iodine-mediated and catalyzed amination of hydrocarbons.
  • To provide mechanistic insights into these reactions.
  • To highlight the role of hypervalent iodine(III) reagents.

Main Methods:

  • Review of literature on hypervalent iodine-mediated amination reactions.
  • Analysis of reactions involving intra- and intermolecular control.
  • Focus on functionalization of sp-, sp(2)-, and sp(3)-hybridized carbon atoms.

Main Results:

  • Hypervalent iodine(III) methodology has significantly advanced hydrocarbon amination.
  • Successful amination of aromatic C-H bonds and various carbon hybridization states.
  • Demonstrated utility in both intramolecular and intermolecular reaction designs.

Conclusions:

  • Hypervalent iodine chemistry is a powerful tool for hydrocarbon amination.
  • The field has reached a high level of sophistication.
  • Further exploration of hypervalent iodine reagents and their mechanisms is warranted.