Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

11.4K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
11.4K
Hematopoiesis01:21

Hematopoiesis

9.8K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
9.8K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.4K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.4K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

4.3K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
4.3K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.1K
Erythropoiesis01:14

Erythropoiesis

6.7K
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human haematopoietic stem cells remember inflammatory stress.

Nature·2026
Same author

Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging.

The Journal of experimental medicine·2025
Same author

CellNEST reveals cell-cell relay networks using attention mechanisms on spatial transcriptomics.

Nature methods·2025
Same author

Hematopoietic Single Cell Atlas Reveals a Diverse Repertoire of Lymphoid Cells in Larval Zebrafish.

bioRxiv : the preprint server for biology·2025
Same author

Splicing of erythroid transcription factor is associated with therapeutic response in myelodysplastic syndromes.

The Journal of clinical investigation·2025
Same author

Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging.

Cell stem cell·2024

Related Experiment Video

Updated: Mar 30, 2026

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
11:50

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

16.0K

Hematopoiesis "awakens": Evolving technologies, the force behind them.

Eugenia Flores-Figueroa1, Marieke Essers2, Teresa V Bowman3

  • 1Oncology Research Unit, Oncology Hospital, National Medical Center, IMSS, Mexico City, Mexico.

Experimental Hematology
|November 8, 2015
PubMed
Summary

The 44th International Society for Experimental Hematology meeting highlighted technological innovations in hematopoiesis research. Advances in single-cell "omics" and imaging are key to understanding hematopoietic stem cell (HSC) identity and function.

More Related Videos

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

12.0K
Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

7.8K

Related Experiment Videos

Last Updated: Mar 30, 2026

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
11:50

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

16.0K
Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

12.0K
Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

7.8K

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Molecular Biology

Background:

  • The 44th International Society for Experimental Hematology (ISEH) meeting convened in Kyoto, Japan, in September 2015.
  • The meeting focused on recent technological advancements impacting the study of hematopoiesis.
  • Key themes included the hematopoietic stem cell (HSC) niche, cellular heterogeneity, stress responses, and epigenetics.

Purpose of the Study:

  • To review key advances in experimental hematology presented at the 2015 ISEH meeting.
  • To highlight the role of emerging technologies in understanding hematopoiesis.
  • To discuss the implications of these advances for cellular identity and aging.

Main Methods:

  • The review synthesizes findings presented at the ISEH meeting.
  • Focus on innovations in single-cell "omics" technologies (e.g., genomics, transcriptomics).
  • Emphasis on advanced imaging techniques for cellular analysis.

Main Results:

  • Technological innovations, particularly single-cell "omics" and imaging, are revolutionizing hematology.
  • New insights were presented on the hematopoietic stem cell (HSC) niche and its role in regulating hematopoiesis.
  • Understanding of HSC heterogeneity, stress responses, and epigenetic regulation has significantly advanced.
  • Changes in these processes across the lifespan, from birth to old age, were discussed.

Conclusions:

  • The future of hematology is being shaped by technological breakthroughs.
  • Single-cell "omics" and imaging are crucial for unraveling complex questions of cellular identity in hematopoiesis.
  • Continued technological innovation promises deeper understanding of hematopoietic stem cells and their functions throughout life.