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Published on: August 11, 2015
Cell Therapy for Intracranial Aneurysms: A Review
Amin Adibi1, Arindom Sen2, Alim P Mitha3
1Pharmaceutical Production Research Facility (PPRF), Schulich School of Engineering, University of Calgary, Calgary, Alberta, Canada; Department of Clinical Neurosciences, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada.
Cell therapy shows promise for preventing intracranial aneurysm recurrence after endovascular coiling. This approach targets cellular processes to improve healing and reduce treatment failure, offering a potential advancement in neurovascular care.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Biomedical Engineering
Background:
- Endovascular coiling is the standard for intracranial aneurysms but has a 20% recurrence rate due to poor healing.
- Aneurysm recurrence is a significant clinical challenge, driving research into improved treatment strategies.
Purpose of the Study:
- To review preclinical studies on cell therapy for intracranial aneurysms.
- To evaluate the potential of cell therapy in improving aneurysm healing and reducing recurrence.
Main Methods:
- Systematic review of ten preclinical studies published between 1999 and 2014.
- Analysis of cell therapy's impact on cellular processes involved in aneurysm healing.
Main Results:
- Cell therapy demonstrated potential in promoting tissue regeneration at aneurysm sites.
- Targeting cellular mechanisms via cell therapy may enhance healing post-embolization.
Conclusions:
- Cell therapy presents a promising avenue for addressing intracranial aneurysm recurrence.
- Further research is needed to overcome current limitations and advance cell therapy for clinical application.
