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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Isolation and Analysis of Hematopoietic Stem Cells from the Placenta
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Isolation and Analysis of Hematopoietic Stem Cells from the Placenta

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Placental stem cells.

Eleni Antoniadou1, Anna L David2

  • 1Stem Cells and Regenerative Medicine Section, Developmental Biology and Cancer Programme, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|November 9, 2015
PubMed
Summary
This summary is machine-generated.

Placenta-derived cells are a rich source for regenerative medicine, capable of differentiating into many cell types. Research is advancing their therapeutic potential in cell transplantation and therapy.

Keywords:
biobankingchorionic mesenchymal stromal cells (hCMSCs)human amniotic epithelial cells (hAECs)human amniotic mesenchymal stromal cells (hAMSCs)placental stem cells

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Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta
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Area of Science:

  • Stem Cell Biology
  • Regenerative Medicine
  • Cell Therapy

Background:

  • The placenta contains progenitor, stem, and epithelial cells with multipotent differentiation capabilities.
  • These cells can differentiate into various lineages, including adipogenic, osteogenic, myogenic, hepatogenic, cardiac, pancreatic, endothelial, pulmonary, and neurogenic types.

Purpose of the Study:

  • To review the properties of placenta-derived cells.
  • To evaluate their current therapeutic applications in regenerative medicine and cell transplantation.
  • To discuss advances in placental stem cell characterization and potential uses in cell therapy.

Main Methods:

  • Review of ongoing clinical and preclinical studies.
  • Analysis of research on human amniotic epithelial cells (hAECs), human amniotic mesenchymal stromal cells (hAMSCs), and chorionic mesenchymal stromal cells (hCMSCs).

Main Results:

  • Placental stem cells offer diverse cell lineages, including hematopoietic and mesenchymal.
  • Ongoing studies assess the safety and efficacy of specific placental cell types for therapeutic use.

Conclusions:

  • Placental stem cells hold significant promise for regenerative medicine and cell therapy.
  • Establishing biobanks for placental stem cells is crucial for clinical translation.