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Antioxidant therapy in the elderly with tinnitus
José Fernando Polanski1, Alexandra Dezani Soares2, Oswaldo Laércio de Mendonça Cruz3
1Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil; Hospital de Clínicas, Federal University of Paraná (UFPR), Curitiba, PR, Brazil.
Introduction:
Several approaches have been tried for the treatment of tinnitus, from cognitive-behavioral therapies and sound enrichment to medication. In this context, antioxidants, widely used in numerous areas of medicine, appear to represent a promising approach for the control of this symptom, which often is poorly controlled.
Objective:
To evaluate the effects of antioxidant therapy for tinnitus in a group of elderly patients.
Methods:
Prospective, randomized, double-blinded, placebo-controlled clinical trial. The sample consisted of 58 subjects aged 60 years or older, with a complaint of tinnitus associated with sensorineural hearing loss. These individuals completed the Tinnitus Handicap Inventory (THI) questionnaire before and after six months of therapy. The treatment regimens were: Ginkgo biloba dry extract (120mg/day), α-lipoic acid (60mg/day)+vitamin C (600mg/day), papaverine hydrochloride (100mg/day)+vitamin E (400mg/day), and placebo.
Results:
There was no statistically significant difference between THI by degree (p=0.441) and by score (p=0.848) before and after treatment.
Conclusion:
There was no benefit from the use of antioxidant agents for tinnitus in this sample.
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