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Related Experiment Videos

Staphylococcus aureus bacteraemia associated with injected new psychoactive substances.

D J Griffith1, C L Mackintosh1, D Inverarity2

  • 1Regional Infectious Diseases Unit,Western General Hospital,Edinburgh,UK.

Epidemiology and Infection
|November 10, 2015
PubMed
Summary

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Injecting new psychoactive substances (NPS) is linked to severe Staphylococcus aureus bacteraemia (SAB) complications like endocarditis. This rise in NPS-related SAB impacts public health targets in Lothian.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Toxicology

Background:

  • Injecting drug use is a known risk factor for deep-seated infections.
  • An increase in new psychoactive substances (NPS) injection has been observed in Lothian, Scotland.
  • Patients injecting NPS have presented with severe Staphylococcus aureus bacteraemia (SAB).

Purpose of the Study:

  • To describe a case series of SAB in patients who inject NPS.
  • To compare the incidence of specific complications between NPS injectors and opiate injectors.
  • To assess the impact of NPS-related SAB on regional public health targets.

Main Methods:

  • Case series analysis of 14 episodes of SAB in ten patients.
  • Comparison of complication rates (endocarditis, pulmonary lesions) between NPS and opiate injectors.
Keywords:
Bloodstream infectionsStaphylococcus aureusendocarditisinjecting drug usepulmonary abscess

Related Experiment Videos

  • Analysis of SAB incidence trends in relation to NPS use.

    • Main Results:

    • NPS users showed a significantly higher incidence of endocarditis and cavitating pulmonary lesions compared to opiate-only injectors (P < 0.05).
    • SAB cases in NPS injectors significantly increased the overall SAB incidence in people who inject drugs (P < 0.05).
    • This rise has affected Lothian's ability to meet national SAB reduction targets.

    Conclusions:

    • Injecting NPS is associated with a higher risk of severe complications, including endocarditis and pulmonary lesions.
    • The rise in NPS-related SAB poses a significant public health challenge, impacting regional control efforts.
    • Urgent attention is needed to address the health consequences of NPS injection.