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Updated: Mar 30, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

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Discovering of Tumor-targeting Peptides using Bi-functional Microarray.

Weizhi Wang¹, Zihua Wang¹, Xiangli Bu¹

¹CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China.

Advanced Healthcare Materials

|November 10, 2015

Summary

This summary is machine-generated.

A novel microarray enables in situ peptide screening, identifying an EpCAM-targeting peptide for effective tumor cell capture. This advancement aids in developing new diagnostic and therapeutic strategies for cancer.

Keywords:

bi-functional capture circulating tumor cells microarray peptide

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Area of Science:

Biotechnology
Molecular Biology
Cancer Research

Background:

Tumor cell capture is crucial for cancer diagnosis and therapy.
Developing targeted affinity peptides requires efficient screening methods.

Purpose of the Study:

To develop a bi-functional microarray for in situ peptide screening.
To identify a peptide with high affinity for EpCAM (Epithelial Cell Adhesion Molecule) for tumor cell capture.

Main Methods:

Design and fabrication of a bi-functional microarray platform.
In situ screening of peptide libraries using the microarray.
Affinity-based selection of peptides targeting EpCAM.

Main Results:

Successful implementation of the bi-functional microarray for peptide screening.
Identification of a specific peptide exhibiting high affinity for EpCAM.
Demonstration of the screened peptide's capability for tumor cell capture.

Conclusions:

The developed microarray is an effective tool for in situ screening and identification of affinity peptides.
The EpCAM-targeting peptide holds potential for applications in cancer diagnostics and therapeutics.
This approach facilitates the discovery of novel reagents for targeted cancer cell isolation.