Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

928
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
928

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emerging Diagnostic Tools and Therapeutic Approaches for Liver Cirrhosis Management.

Current pharmaceutical design·2026
Same author

Optimized polymeric micellar In situ gel formulation incorporating luliconazole for targeted management of fungal endophthalmitis: In vitro characterization, ex vivo ocular permeation, and in vivo ocular irritation evaluation.

Experimental eye research·2026
Same author

Microbial engineering for pesticide degradation: current insights and future directions for sustainable agriculture.

Frontiers in microbiology·2026
Same author

Sleep, BDNF, and beyond: A comparative study of zolpidem and clobazam in insomnia treatment.

Sleep medicine·2025
Same author

Immunomodulatory Potential of Escitalopram on C-C Motif Chemokine Ligand 5 and Fibroblast Growth Factor 2 in Patients With Generalised Anxiety Disorder.

Human psychopharmacology·2025
Same author

Correction: The Psychological Impact of Rhino-Orbital Mucormycosis During the Second Wave of COVID-19 Pandemic From South East Asian Country.

Cureus·2025

Related Experiment Video

Updated: Mar 30, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.5K

A Diffusion Tensor Imaging Study Using a Voxel-Based Analysis, Region-of-Interest Method to Analyze White Matter

Shruti Srivastava1, Manjeet S Bhatia1, S K Bhargava1

  • 1From the Depts. of Psychiatry (SS, MSB) and Radiology (SKB), University College of Medical Sciences and Guru Tegh Bahadur Hospital, Dilshad Garden, Delhi, India; the Dept. of Neuroradiology, Institute of Human Behavior and Allied Sciences, Dilshad Garden, Delhi, India (RK); and the BioMedical Dept., Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation, New Delhi, India (SC).

The Journal of Neuropsychiatry and Clinical Neurosciences
|November 10, 2015
PubMed
Summary

This study found lower fractional anisotropy (FA) in the brains of patients with major depressive disorder (MDD). These FA values may serve as early biomarkers for MDD.

More Related Videos

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

26.0K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

9.1K

Related Experiment Videos

Last Updated: Mar 30, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.5K
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

26.0K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

9.1K

Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neurology

Background:

  • Major depressive disorder (MDD) is a prevalent mental health condition.
  • Understanding the neurobiological underpinnings of early-stage MDD is crucial for effective treatment.
  • White matter abnormalities are increasingly implicated in the pathophysiology of MDD.

Purpose of the Study:

  • To investigate white matter integrity using diffusion tensor imaging (DTI) in first-episode, treatment-naïve patients with MDD.
  • To identify specific brain regions affected by white matter abnormalities in early MDD.
  • To evaluate the utility of fractional anisotropy (FA) as a potential biomarker for MDD.

Main Methods:

  • Diffusion tensor imaging (DTI) was employed to measure fractional anisotropy (FA).
  • Two analysis techniques were utilized: automated voxel-based analysis and a region-of-interest (ROI) method.
  • Magnetic resonance imaging (MRI) at 3 Tesla was performed on 15 patients with first-episode MDD and 15 age-matched healthy controls.

Main Results:

  • Patients with MDD exhibited significantly lower FA values compared to controls.
  • Reduced FA was observed in the left superior longitudinal fasciculus, left prefrontal cortex, and left parietal region.
  • The ROI method specifically identified significantly lower FA in the right hippocampus of MDD patients.

Conclusions:

  • Fractional anisotropy (FA) values are altered in the white matter of individuals with early-stage, treatment-naïve major depressive disorder (MDD).
  • Specific regions, including the left superior longitudinal fasciculus, left prefrontal cortex, left parietal region, and right hippocampus, show significant white matter abnormalities.
  • Voxel-based analysis and ROI methods complement each other, highlighting FA as a promising imaging biomarker for early MDD detection and characterization.