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Hydroxyurea-induced oral ulceration.

Maha Badawi¹, Soulafa Almazrooa², Fatima Azher³

¹Assistant Professor, Department of Hematology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

|November 10, 2015

Summary

Hydroxyurea, a common antimetabolite, can cause oral ulceration as a side effect. Discontinuing the drug often resolves these lesions, highlighting the need for physician and dentist awareness.

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Area of Science:

Pharmacology
Oncology
Oral Medicine

Background:

Hydroxyurea is a widely used antimetabolite for treating various benign and malignant conditions.
While generally well-tolerated, hydroxyurea can cause side effects requiring treatment modification.
Adverse events necessitate a balance between treatment benefits and drug-induced harm.

Observation:

A case report details oral ulceration in a patient undergoing hydroxyurea treatment for chronic myelogenous leukemia.
The patient developed a significant oral ulcer approximately 12 days after starting hydroxyurea.
The oral lesion showed marked improvement upon temporary or permanent discontinuation of hydroxyurea.

Findings:

Hydroxyurea treatment was associated with the development of oral ulceration.
Cessation of hydroxyurea led to a noticeable decrease in the severity and size of the oral lesion.
This case underscores a potential adverse drug reaction to hydroxyurea.

Implications:

Physicians and dentists should be vigilant for oral ulceration as a potential side effect of hydroxyurea.
Awareness of this association can lead to timely diagnosis and management of hydroxyurea-induced oral lesions.
This finding contributes to the understanding of hydroxyurea's side effect profile in clinical practice.