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Updated: Mar 30, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Novel systemic therapies for the treatment of psoriasis
Ki-Wei Tan1,2, Christopher E M Griffiths1
1a Dermatology Centre, Manchester Academic Health Science Centre, Salford Royal Hospital , University of Manchester, Manchester , UK.
Introduction:
The immunopathogenesis of psoriasis has led to the discovery and development of several promising treatment options for psoriasis, including those that target the IL-17 and IL-23 pathways as well as small molecules that act on intracellular signaling pathways including the Janus kinase inhibitor and phosphodiesterase-4 inhibitor. Studies have demonstrated efficacy although long-term risks are not fully known. This review looks at novel systemic therapies for psoriasis that have emerged recently.
Areas Covered:
Systemic treatments for psoriasis that are in the late phase of development were reviewed, with the main focus on the efficacy and adverse effects of individual treatments.
Expert Opinion:
The future of psoriasis treatment is likely to be based on clinical, genetic and immune biomarkers that will individualize treatment and may potentially optimize disease outcome.
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