Related Experiment Video

Updated: Mar 30, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

10.2K

Modulation of p53 during bacterial infections

Christine Siegl1,2, Thomas Rudel1

  • 1Department of Microbiology, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany.

Nature Reviews. Microbiology
|November 10, 2015
PubMed

Insights

Bacterial pathogens inactivate the tumor suppressor p53, hindering host defenses and impacting host cell metabolism. This interaction is crucial for understanding how bacteria cause disease and how p53 combats infections.

Area of Science:

  • Microbiology
  • Cell Biology
  • Immunology

Background:

  • Pathogenic bacteria frequently inactivate the tumor suppressor p53, a key protein in host cell defense.
  • p53 inactivation compromises the host cell's response to genotoxicity caused by bacterial infections.
  • Emerging evidence shows p53's role in downregulating host cell metabolism to inhibit bacterial replication.

Purpose of the Study:

  • To summarize recent advancements in understanding the interplay between pathogenic bacteria and the p53 protein.
  • To discuss the implications of these host-pathogen interactions for disease development.

Main Methods:

  • Literature review of recent research on bacterial pathogens and p53.
  • Analysis of the functional outcomes of p53 inactivation by bacteria.
  • Discussion of p53's role in modulating host cell metabolism during infection.

Main Results:

  • Bacterial pathogens actively target and inactivate p53, a critical tumor suppressor.
  • p53's role extends to regulating host cell metabolism, impacting intracellular bacterial growth.
  • The interaction between bacteria and p53 significantly influences pathogenesis.

Conclusions:

  • p53 plays a multifaceted role in host defense against bacterial pathogens, including managing genotoxicity and controlling host metabolism.
  • Understanding bacterial manipulation of p53 is vital for developing new therapeutic strategies against intracellular bacterial infections.

More Related Videos

Purification of Ubiquitinated p53 Proteins from Mammalian Cells10:55

Purification of Ubiquitinated p53 Proteins from Mammalian Cells

Published on: March 21, 2022

2.9K
Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence04:56

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

326

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
3.4K
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
10.4K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.9K
Stringent Response in E. coli01:23

Stringent Response in E. coli

Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
467
Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
36