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Targeting intrinsically disordered proteins in rational drug discovery

Susmitha Ambadipudi1, Markus Zweckstetter1,2,3

  • 1a German Center for Neurodegenerative Diseases (DZNE) , 37077 Göttingen , Germany.

Expert Opinion on Drug Discovery
|November 10, 2015
PubMed
Summary

Intrinsically disordered proteins (IDPs) are crucial in cell function and disease. Advances in detection and characterization are enabling new drug discovery strategies targeting protein disorder.

Keywords:
NMR spectroscopydrug discoveryintrinsically disordered proteinneurodegeneration

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