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Related Experiment Video

Updated: Mar 30, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Clostridium difficile infection and intestinal microbiota interactions.

C Rodriguez¹, B Taminiau¹, J Van Broeck²

¹Food Science Department, FARAH, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.

Microbial Pathogenesis

|November 10, 2015

Summary

Clostridium difficile causes healthcare-associated diarrhea globally. Studying gut microbiota offers new treatments like fecal microbiota transplantation for Clostridium difficile infection (CDI) and prevention strategies.

Keywords:

Clostridium difficile Colonisation Infection Intestinal microbiota

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Last Updated: Mar 30, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

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Published on: December 10, 2016

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

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Published on: December 8, 2014

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Area of Science:

Microbiology
Gastroenterology
Infectious Diseases

Background:

Clostridium difficile is a primary cause of hospital-acquired diarrhea, with ongoing global outbreaks.
It's also emerging as a significant community pathogen and is found asymptomatically in neonates, adults, and animals.
Understanding the gut microbiome is crucial for managing C. difficile infections.

Purpose of the Study:

To investigate the role of intestinal microbiota in Clostridium difficile infection (CDI).
To identify new therapeutic and prophylactic strategies for CDI based on gut microbiota modulation.

Main Methods:

Analysis of gut microbial communities in healthy individuals and CDI patients.
Review of existing data on the gut microbiome and its relation to C. difficile.

Main Results:

Findings highlight the significant impact of gut microbiota composition on C. difficile infection.
Data suggests potential for microbiota-based interventions in treating and preventing CDI.

Conclusions:

Intestinal microbiota plays a critical role in both health and C. difficile infection.
Modifying gut microbiota presents promising avenues for novel CDI treatments, including fecal microbiota transplantation and functional foods.