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Related Concept Videos

Patterns of Fever01:26

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Before understanding the types and patterns of fever, it is essential to know its phases.
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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Methods of reducing fever01:22

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The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
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Acute Pharyngitis01:30

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Related Experiment Video

Updated: Mar 30, 2026

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
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[Recurrent fevers in childhood].

Maryam Piram1, Isabelle Koné-Paut1

  • 1AP-HP, université Paris Sud, CHU de Bicêtre, centre de référence des maladies auto-inflammatoires de l'enfant (CeRéMAI)(1), service de rhumatologie pédiatrique, 78, rue du Général-Leclerc, 94270 le Kremlin-Bicêtre, France.

Presse Medicale (Paris, France : 1983)
|November 10, 2015
PubMed
Summary
This summary is machine-generated.

Hereditary recurrent fevers (HRF) are rare genetic disorders causing repeated fever episodes. Early diagnosis, often aided by genetic testing, is crucial to manage complications like AA amyloidosis.

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Area of Science:

  • Genetics
  • Immunology
  • Internal Medicine

Context:

  • Hereditary recurrent fevers (HRF) are rare Mendelian diseases.
  • These conditions involve inherited mutations affecting innate immunity pathways.
  • Recurrent fevers manifest as stereotypical febrile episodes over months or years.

Purpose:

  • To define and differentiate hereditary recurrent fevers from other febrile illnesses.
  • To highlight key diagnostic clues for suspecting HRF.
  • To underscore the importance of genetic diagnosis in monogenic HRF.

Summary:

  • Recurrent fevers are characterized by multiple, similar febrile episodes with symptom-free intervals.
  • Hereditary recurrent fevers stem from genetic mutations impacting innate immunity.
  • Key indicators include childhood onset, family history, and inflammatory symptoms, with AA amyloidosis as a common complication.

Impact:

  • Facilitates accurate diagnosis of rare genetic fever syndromes.
  • Distinguishes HRF from intermittent infectious fevers, improving patient management.
  • Emphasizes the role of genetic testing in confirming monogenic HRF.