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Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction

Margaret M Redfield1, Kevin J Anstrom, James A Levine

  • 1From the Mayo Clinic, Rochester, MN (M.M.R., B.A.B., H.H.C.); Duke Clinical Research Institute (K.J.A., S.E.M., E.J.V.) and Duke University Medical Center (G.M.F.) - both in Durham, NC; Mayo Clinic, Scottsdale, AZ (J.A.L., G.A.K.); University of Vermont Medical Center, Burlington (M.M.L.); Washington University School of Medicine, St. Louis (S.M.J.); Northwestern University, Chicago (S.J.S.); Massachusetts General Hospital (M.J.S.) and Harvard Medical School (E.B.) - both in Boston; Emory University, Atlanta (R.T.C.); Thomas Jefferson University, Philadelphia (G.R.R.); Johns Hopkins University School of Medicine, Baltimore (R.J.T.), and the National Heart, Lung, and Blood Institute, Bethesda (M.R.S.) - both in Maryland; and the Cleveland Clinic Foundation, Cleveland (W.H.W.T.).

The New England Journal of Medicine
|November 10, 2015
PubMed
Summary

Isosorbide mononitrate did not improve activity tolerance in patients with heart failure with preserved ejection fraction. This nitrate medication significantly reduced daily activity and hours of activity compared to placebo.

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