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Ineffective VTA Disinhibition in Protracted Opiate Withdrawal
1Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, 5 rue Blaise Pascal, 67084 Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Trends in Neurosciences
|November 10, 2015
Abstract:
Recently, Kaufling and Aston-Jones showed that, under protracted opiate withdrawal, control of dopamine activity by the tail of the ventral tegmental area shifts from a bidirectional influence towards one-way inhibition. Beyond dysphoric states accompanying withdrawal, these results may also impact research on depression and individual differences in coping and affect.