Neuropeptide Y: An Anti-Aging Player?
Mariana Botelho1, Cláudia Cavadas1
1CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Trends in Neurosciences
|November 10, 2015
Summary
Neuropeptide Y (NPY) influences aging and lifespan. This review explores how NPY affects key aging hallmarks, offering insights into age-related damage and potential interventions.
Area of Science:
- Neuroscience
- Gerontology
- Molecular Biology
Background:
- Neuropeptide Y (NPY) is increasingly recognized for its involvement in aging processes.
- Age-related alterations in NPY levels are observed in the brain.
Purpose of the Study:
- To critically review the role of NPY in aging and lifespan determination.
- To examine the impact of NPY on the six core hallmarks of aging.
Main Methods:
- Literature review and critical discussion of existing research.
- Analysis of age-related changes in NPY levels.
- Synthesis of findings on NPY's contribution to aging hallmarks.
Main Results:
- NPY levels change with age in the brain.
- NPY is implicated in processes such as loss of proteostasis, stem cell exhaustion, altered intercellular communication, deregulated nutrient sensing, cellular senescence, and mitochondrial dysfunction.
Conclusions:
- NPY plays a complex role in aging, potentially both contributing to and counteracting age-related decline.
- Further research into NPY's mechanisms can reveal new strategies for mitigating aging damage.
Keywords:
autophagycaloric restrictionhallmarks of aginginflammationneuropeptide Ysenescencestem cellsMore Related Videos
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