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Updated: Mar 30, 2026

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Click Reaction: An Applicable Radiolabeling Method for Molecular Imaging.

Ji Young Choi1, Byung Chul Lee2

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Click chemistry offers a powerful tool for radiochemistry, enabling the rapid synthesis of novel radiotracers. These advancements are crucial for developing new molecular imaging agents for biomacromolecules.

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Area of Science:

  • Radiochemistry
  • Chemical Biology
  • Molecular Imaging

Background:

  • The click reaction has emerged as a significant methodology in modern chemistry.
  • Its application in radiochemistry has expanded, particularly for labeling biomacromolecules.
  • This has opened new avenues for molecular imaging techniques.

Purpose of the Study:

  • To review the development of click chemistry reactions for radiolabeling.
  • To highlight the reliability, power, and selectivity of these reactions.
  • To showcase their utility in synthesizing novel radiotracers for molecular imaging.

Main Methods:

  • Review of recent literature on click chemistry in radiochemistry.
  • Analysis of reaction mechanisms and their suitability for radiolabeling.
  • Evaluation of selectivity and efficiency for tracer synthesis.

Main Results:

  • Click chemistry provides highly reliable and selective methods for radiotracer synthesis.
  • These reactions facilitate the rapid preparation of labeled biomacromolecules.
  • Significant progress has been made in developing powerful click reactions for imaging.

Conclusions:

  • Click chemistry is a transformative tool in radiochemistry and molecular imaging.
  • The reviewed reactions enable efficient and rapid synthesis of advanced radiotracers.
  • Continued development promises further innovation in biomacromolecular imaging.