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Correlation of NGX6 expression with clinicopathologic features and prognosis in colon cancer
Jidong Xiao1, Yuanquan Zhou1, Bo Liu2
1Department of Diagnostic Ultrasound, Third Xiangya Hospital, Central South University Changsha 410013, Hunan Province, China.
Objective:
The aim was to explore the correlation of NGX6 expression with clinicopathological features and prognosis in colon cancer.
Methods:
Clinicopathological feature of 145 patients with colon cancer were analyzed.NGX6 expression was measured using immunohistochemistry methods. The correlation of NGX6 expression with clinicopathological features and prognosis were assessed.
Results:
Among 145 cases of colon cancer, NGX6 positive expression were found in 76 (52.4%) cases and NGX6 negative expression were found in 69 (47.6%) cases. The expression of NGX6 was closely associated with size tumor, lymph node metastasis and TNM stage (P=0.002, 0.012, and 0.039, respectively). Kaplan-Meier analysis showed that NGX6 negative expression was associated with shorter disease-free survival (DFS) (P=0.029) and overall survival (OS) (P=0.015). Multivariate survival analysis demonstrated that NGX6 expression was the important independent prognostic factor for colon cancer (P=0.022).
Conclusion:
NGX6 is involved in the invasion and metastasis activity of colon cancer. NGX6 could may be applied as a novel and promising prognostic marker for colon cancer.
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