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Updated: Mar 30, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
Published on: October 10, 2025
The association between SDF-1 G801A polymorphism and non-small cell lung cancer risk in a Chinese Han population
Weiguo Xu1, Rong Cui2, Huapeng Yu3
1Department of Respiratory, Zhujiang Hospital, Southern Medical University Guangzhou, China ; Department of Respiratory, Mianyang Central Hospital Mianyang, China.
Background:
SDF-1 G801A polymorphism is reported to correlate with cancer susceptibility. However, the association between SDF-1 G801A polymorphism and non-small cell lung cancer (NSCLC) risk in Chinese populations remains unknown.
Material And Methods:
A total of 408 NSCLC patients and 303 health controls included in this study. Restriction length fragment polymorphism (RFLP) analysis was used to assess the frequencies of SDF-1 G801A polymorphic variant.
Results:
No significant association was found between SDF-1 G801A polymorphism and NSCLC risk (OR=1.268, 95% CI 0.811-2.583, P=0.361). Furthermore, SDF-1 G801A polymorphism was not correlated with histological type (P=0.697) and TNM stage (P=0.276).
Conclusion:
SDF-1 G801A polymorphism was not a risk factor for NSCLC in Chinese Han population.
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