Analysis on correlation of white matter lesion and lacunar infarction with vascular cognitive impairment
Ting Yan1, Jia-Rui Yu1, Yun-Pei Zhang1
1Department of Imaging, The Third Hospital of Ji Nan Shandong, China.
Objective:
To investigate the correlation of white matter lesion (WML) and lacunar infarction (LI) with vascular cognitive impairment. To investigate the correlation of cognitive changes of vascular dementia (VD) patients with lacunar infarction (LI) and white matter lesion (WML).
Methods:
The clinical data of 60 cases of VD patients were evaluated and analyzed by combining with imageological findings and cognitive function assessment.
Results:
Multiple LI and WML were negatively correlated with both mini-mental state examination (MMSE) scale scores (r = -0.401, P = 0.036) and clock drawing test (CDT) scale scores (r = -0.482, P = 0.028); the LI number in occipital lobe was negatively correlated with MMSE scores (r = 0.338, P = 0.048), the LI number in temporal lobe was negatively correlated with CDT scores (r = -0.235, P = 0.047), and the LI number in frontal lobe was negatively correlated with MoCA scores (r = -0.450, P = 0.039).
Conclusion:
All of LI location and number as well as WML are independent influencing factors of cognitive impairment of VD patients.
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