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Updated: Mar 30, 2026

Measurement of Chitinase Activity in Biological Samples
Published on: August 22, 2019
Clinical use of plasma chitotriosidase in severe sepsis
Carlo Chiarla1, Ivo Giovannini1, Daniela Antuzzi2
1a a CNR-IASI Center for the Pathophysiology of Shock, Catholic University of the Sacred Heart, Agostino Gemelli Hospital , Rome , Italy.
Abstract:
Plasma chitotriosidase activity (ChT) was previously proposed to quantify severity of sepsis. In a complex surgical case, with prolonged sepsis and consistently high ChT, we found that the least increased values occurred in stages of extreme illness, with profound hypocholesterolemia. ChT needs better characterization before becoming a reliable biomarker of septic evolution.
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